Niosomes are now widely studied as an alternative to liposomes. The average vesicular size of niosomes of all the batches was measured in the range of 4. Formulation, characterization and evaluation of morusin loaded niosomes for potentiation of anticancer therapy srishti agarwal,a m. Niosomes are formed mostly by cholesterol incorporation as an excipient. Niosomes are nonionic surfactant based unilamellar or multilamellar bilayer vesicles up on hydration of non ionic surfactants with or without incorporation cholesterol. Niosomes are a novel drug delivery system, in which the medication is. In this case, nonionic surfactants, for example, polyglyceryl alkyl ethers or sphingolipids, make up the bilayers of niosomes and sphingosomes, respectively figure 6. In niosomes, the vesicles forming amphiphilic is a nonionic surfactant such as span 60 which is usually stabilized by addition of. Niosomes are vesicles of nonionic surfactant for example, alkyl ester and alkyl ether and cholesterol that act as a carrier for amphiphilic and.
Niosomes are used for better targeting of the drug at appropriate tissue destination. Niosomes are unilamellar or multilamellar vesicles. Such extensions have been observed in lipospheres of bupivacaine formulations and have been attributed to drug crystals on the surface of the niosomes toongsuwan et al, 2004. The vesicles of span 20based niosomes were distinct, near spherical large unilamellar vesicles.
Niosomes are a novel drug delivery system, in which the medication is encapsulated in a vesicle. Rapid microfluidic preparation of niosomes for targeted drug delivery. Niosomes are made up of uncharged single chain surfactant molecules. In histopathological study no effect of surfactant was seen. Development and characterization of niosomal drug delivery.
Niosomes serve as drug depots in the body which release the drug in a controlled manner through its bilayer providing sustained release of the enclosed drug. Niosomes are one of the promising drug carriers that have a bilayer structure and are formed by selfassociation of nonionic surfactants and cholesterol in an aqueous phase. The vesicle is composed of a bilayer of nonionic surface active agents and hence the name niosomes. Niosomes are microscopic lamellar structures, which are formed on the admixture of nonionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. Niosome using span60 as surfactant, image from niosome liposome are made of phospholipids, th. Paclitaxelloaded niosomes for intravenous administration.
Charcterization of niosomes a entrapment efficiency. The vesicles were discrete and separate with no aggregation or agglomeration figure 1. The release of drug from niosomes is determined using the membrane diffusion technique. Niosomes have more penetrating capability than the previous preparations of emulsions. The diameter of the formulated niosomes was found to be in the range of 12. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Niosomes as carrier in dermal drug delivery intechopen.
The niosomes are very small, and microscopic in size. Niosomes constitute of nonionic surfactant whereas liposomes comprise of phospholipids khan et al. Antitumour activity and pharmacokinetics of niosome encapsulated. Formulation and characterization of topical gel of erythromycin entrapped into niosomes vyas jigar, gajjar vishal, gediya tejas, christian vishal, upadhyay umesh.
Niosomes are formed mostly by nonionic surfactant and cholesterol incorporation as an excipient. Most surfactants have a single hydrophobic tail, eg. The aim of this work was to prepare and evaluate drug loaded niosomes for antifungal activity. Niosomes are vesicular nanocarriers and are receiving much attention as potential transdermal drug delivery systems due to properties such as enhanced drug penetration. On the average, the niosome batches exhibited a narrow size distribution range. Drug targeting can be defined as the ability to direct a therapeutic agent specifically to desired site of action with little or no interaction with non target tissue. Niosomes are widely accepted by research scientist. Contents of the powerpoint on niosomes drug delivery systems include. Sakthi kumar a morusin, a waterinsoluble prenylated. Niosomes are nonionicbased surfactant unilamellar or multilamellar vesicles with a bilayer structure that have been used for around 40 years as drug delivery systems for different applications. Formulation and evaluation of niosomes indian journal of. What is the difference between liposomes and niosomes. Ultrasonic processing technique as a green preparation approach. Similarly to liposomes, they are biodegradable and represent today the more stable and less expensive alternative to.
Pdf design and characterization of ofloxacin niosomes. Niosomes are nonionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. In this study, niosomes containing ciclopirox olamine were prepared by ether injection technique using nonionic surfactant span 40 and span 60 and cholesterol at different concentrations. Formulation and characterization of topical gel of. Niosomes are vesicles composed of nonionic surfactants, amphipathic compounds with an overall neutral charge see fig 1 for the. Niosomes and liposomes are equiactive in drug delivery potential and both increase drug efficacy as compared with that of free drug. Formulation and evaluation of niosomes of benzyl penicillin. Formulation, characterization and evaluation of morusin. Niosomes are microscopic in size and their size lies in the nanometric scale.
The result suggested that niosomes prepared were of uniform size and spherical in shape shown in fig. Paul ehrlich, in 1909, initiated the era of development for targeted delivery when he envisaged a drug delivery mechanism that would target directly to diseased cell. The niosomes entrapped insitu nasal gel formulations showed sufficient quantity of invitro drug release through the gel across the goats nasal mucosa. Niosomes are made of nonionic surfactants and cholesterol. Concentration of the free drug in the supernatant was determined by measuring absorbance at 267 nm with a uv spectrophotometer shimadzu, uv 1650 pc, kyoto, japan. Niosomes are such hydrated vesicular systems containing nonionic surfactants along with cholesterol or other lipids delivering drug to targeted site which are non toxic, requiring less production cost, stable over a longer period of time in different conditions, so overcomes drawbacks of liposome. Toxic drugs which needed higher doses can possibly be delivered safely using niosomal application. The alkyl chain of the surfactants varied between 10 and 18, while the number of oxyethylene units varied between 3 and 7. All the niosomal formulations released diacerein faster than pure drug, and the drug release rates from the niosomes produced by the up method were higher than. Preparation and characterization of giant niosomes masters thesis in nanotechnology maryam homaei department of microtechnology and nanoscience mc2 chalmers university of technology gothenburg, sweden 2016. Vesicles of nonionic surfactants niosomes and drug delivery potential 3 it is determined after separation of unentrapped drug, on complete vesicle disruption by using about 1ml of 2. Get a printable copy pdf file of the complete article 1. Vesicles of nonionic surfactants niosomes and drug. In vitro release rate studies revealed that the cumulative percent rifampicin released was maximum for span20based niosomes and minimum for span85based niosomes table 1.
Niosomes and sphingosomes are names given to vesicles with structures similar to liposomes daniels, 2011. Design and characterization of ofloxacin niosomes article pdf available in pakistan journal of pharmaceutical sciences 266. Niosomes are used in studies for drug delivery or gene transfer. Niosomal suspension shows a visible spectrum superimposable onto that of free hemoglobin. Niosomes or nonionic surfactant vesicles are microscopic lamellar. Part of theamerican studies commons this thesis is brought to you for free and open access by the graduate school at scholar.
In this paper the forming of vesicles from single chain surfactants, i. Development of valproic acid niosomal in situ nasal gel. Formulation and optimization of zidovudine niosomes. Niosomes are nonionic surfactantbased vesicles with high promise for drug delivery applications. Niosome a future of targeted drug delivery systems temperature change in the niosomal system affects assembl y of su rfactants in to v esicles an d al so induces vesicle. Niosomes, an alternative for liposomal delivery plos. Targeted drug delivery can also be achieved using niosomes the drug is delivered directly to the body part where the therapeutic effect is required. They are structurally similar to liposomes in having a. Structure of niosomes niosomes are microscopic lamellar structures which are formed on the admixture of nonionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in. The handshaking method is a simple and efficient technique for designing functional niosomes for hydrophobic or amphiphilic drugs. From each batch about 100 niosomes were measured for the diameter. Niosomes may be unilamellar or multilamellar depending on the method used to prepare them. Niosomes are biodegradable, biocompatible, and nonimmunogenic.
Niosomes, an alternative for liposomal delivery ncbi. Research article formulation and invitro evaluation of. A diverse range of materials have been used to form niosomes such as sucrose ester surfactants and polyoxyethylene alkyl ether surfactants, alkyl ester, alkyl amides, fatty acids and. They are structurally similar to liposomes in having a bilayer, however, the materials used to prepare niosomes make them more. They are functionally the same, have the same physical properties and act. Synthesis and characterization of potential drug delivery. Niosomes and liposomes have similar application in drug delivery but chemically differ in structure units. Niosomes are a novel drug delivery system, which entrapped the hydrophilic drug in the core cavity and hydrophobic drugs in the nonpolar. Masters thesis 2016 preparationandcharacterization ofgiantniosomes. Synthesis and characterization of potential drug delivery systems using nonionic surfactant niosome sukit leekumjorn university of south florida follow this and additional works at. Thakur varun, arora sonia, prashar bharat and vishal patil.
Research article formulation and characterization of drug. Recent trends in niosome as vesicular drug delivery system. Niosomes are formed on the admixture of nonionic surfactant of the alkyl or dialkylpolyglycerol ether class and cholesterol with subsequent hydration in aqueous media. Niosomes were prepared by the thin film hydration method followed by gel permeation chromatography to obtain purified niosome suspensions. Cationic niosomes for nucleic acid delivery are made up of several elements including. Niosomes are multilamellar vesicles formed from nonionic surfactants of the alkyl or.
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